The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
申请公布号
WO9900357(A1)
申请公布日期
1999.01.07
申请号
WO1998US13496
申请日期
1998.06.29
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
SALITURO, FRANCESCO, GERALD;BEMIS, GUY, W.;GREEN, JEREMY;KOFRON, JAMES, L.