发明名称 |
3'-MONOPHOSPHORYLATING OLIGONUCLEOTIDES |
摘要 |
3'-Monophosphorylating oligonucleotides are provided, which stability in serum and endocellular is markedly higher than that of non-modified oligonucleotides and a little higher than that of phosphorothioate-modified oligonucleotides demonstrated by studying them in vitro and cell, which ability to uptake by cell is higher than that of non-modified oligonucleotides and phosphorothioate-modified oligonucleotides. Its products of metabolic degradation do not have any toxycity and side effect, due to 3'-monophosphorylating oligonucleotides not containing non-natural modification elements. Therefore, when used as therapeutic agents, 3'-monophosphorylating oligonucleotides are more advantageous and safer than phosphorothioate-modified oligonucleotides.
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申请公布号 |
WO9900401(A1) |
申请公布日期 |
1999.01.07 |
申请号 |
WO1998CN00102 |
申请日期 |
1998.06.26 |
申请人 |
SHANGHAI INSTITUTE OF BIOCHEMISTRY, CHINESE ACADEMY OF SCIENCES;LU, CHANG-DE;ZHUANG, MIN;XIA, YU-LEI |
发明人 |
LU, CHANG-DE;ZHUANG, MIN;XIA, YU-LEI |
分类号 |
C12N15/09;A61K31/7088;A61K48/00;C07H21/00;C07H21/02;C07H21/04;(IPC1-7):C07H21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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