| 摘要 |
PROBLEM TO BE SOLVED: To provide a new human endoglin gene promoter containing a specific sequence, a functional part or variant, capable of controlling the transcription and translation of an effector gene and useful for gene therapy, etc. SOLUTION: This new human endoglin gene promoter contains the sequence expressed by the formula, its functional part or its variant and is capable of controlling the transcription and translation of an effector gene inserted into a cell. It is useful as a strong and endothelially specific promoter capable of producing an agent for the treatment of tumors, leukemia, autoimmune diseases, allergy, arthritis, inflammation, rejection of organs, graft versus host reaction, blood coagulation diseases, cardiovascular diseases, anemia, infection, CNS damage, etc., and usable for gene therapy. The promoter can be produced by cloning a human endoglin cDNA with a promoter finder DNA working kit. |
