发明名称 Method of preparing phosphodiesterase IV inhibitors
摘要 This invention is concerned with a novel process for the preparation of a compound of structural formula I <IMAGE> I wherein R1 and R2 independently are aryl, C2-15 alkenyl or C1-15 alkyl, either unsubstituted or substituted with one or three substituents, which can be the same or different, selected from the group consisting of Ra, wherein Ra belongs to a group consisting of C1-6 alkyl, aryl, halo, -N(R3)2, -NO2, -CN, -OR3, -C3-6 cycloalkoxy, -CO(R3), -COOR3, SO2R3 and -SR3; wherein R3 is selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl and aryl, said alkyl, alkenyl or aryl optionally substituted with 1 to 3 groups of Ra, which is an important antiasthmatic agent.
申请公布号 US5856498(A) 申请公布日期 1999.01.05
申请号 US19970931155 申请日期 1997.09.16
申请人 MERCK & CO., INC. 发明人 DORZIOTIS, ILIAS K.;HOUPIS, IOANNIS N.;LEE, JAEMOON;VOLANTE, RALPH P.
分类号 C07D213/16;C07D213/30;(IPC1-7):C07D213/30;C07D213/127 主分类号 C07D213/16
代理机构 代理人
主权项
地址