Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions

摘要

PCT No. PCT/US94/05285 Sec. 371 Date Nov. 11, 1995 Sec. 102(e) Date Nov. 11, 1995 PCT Filed May 12, 1994 PCT Pub. No. WO94/26786 PCT Pub. Date Nov. 24, 1994The present invention provides compositions comprising at least one complement moiety and at least one carbohydrate moiety, and methods of producing such compositions. In particular, the compositions of the invention comprise complement proteins related to the complement receptor type I, and further comprise ligands for intracellular molecules, such as selectins. In a preferred embodiment, the compositions comprise a complement-related protein in combination with the Louis X antigen or the sialyl Lewis X antigen. The compositions of the invention have use in the diagnosis or therapy of disorders involving complement activity and inflammation. Pharmaceutical compositions are also provided for treating or reducing inflammation mediated by inappropriate complement activity and intercellular adhesion.