Antipicornaviral compounds and methods for their use and preparation
摘要
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
申请公布号
US5856530(A)
申请公布日期
1999.01.05
申请号
US19970850398
申请日期
1997.05.02
申请人
AGOURON PHARMACEUTICALS, INC.
发明人
WEBBER, STEPHEN E.;DRAGOVICH, PETER S.;PRINS, THOMAS J.;REICH, SIEGFRIED H.;LITTLE, JR., THOMAS L.;LITTLEFIELD, ETHEL S.;MARAKOVITS, JOSEPH T.;BABINE, ROBERT E.;BLECKMAN, TED M.