发明名称 |
IMIDAZOLIN DERIVATIVES AND A METHOD FOR PRODUCING THE SAME AND A THERAPEUTIC AGENT FOR MAINTAINING BLOOD PRESSURE |
摘要 |
(1) The imidazoline derivative represented by the following general formula (1) (see fig. I) where R1 is a substituent endowed with water solubility or fat solubility, particularly carboxyl group or carboxymethoxy group or a pharmaceutically acceptable salt thereof, (2) The method for producing the above-mentioned compound, and (3) A therapeutic agent containing as its active ingredient the above-mentioned imidazoline derivative or an imidazoline derivative wherein R1 indicated in the formula (1) is hydrogen atom. The imidazoline derivative set forth under (1) above is a novel substance; and this compound itself and its derivative having R1 as indicated in the general formula (1) is hydrogen atom are useful as a therapeutic agent for treatment of shock from the fall in blood pressure by virtue of their ability to remove excess NO which is the vascular endothelium-derived relaxing factor (EDRF).
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申请公布号 |
CA2132017(C) |
申请公布日期 |
1999.01.05 |
申请号 |
CA19932132017 |
申请日期 |
1993.01.14 |
申请人 |
MAEDA, HIROSHI |
发明人 |
AKAIKE, TAKAAKI;MAEDA, HIROSHI;MIYAMOTO, YOICHI |
分类号 |
A61K31/415;C07D233/06;C07D233/08;C07D233/26;(IPC1-7):C07D233/06 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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