PREPARATION OF SUBSTITUTED ETHENES

摘要

A potassium salt useful in the production of certain N-substituted alkyl or aryl alkyl thionitroethenamines is produced by the reaction of the dipotassium salt of a 2-nitrodithio aliphatic acid such as 2 -nitrodithio acetic acid with branched chain primary alkylamines, secondary alkylamines, arylalkylamines or heterocyclic alkylamines such as dimethylamine, pinacolylamine, benzylamine or piperonylamine, thereby converting one only of the KS-groups to a n alkylamine group. The resulting monopotassium salt may be alkylated or arylalkylated to produce an N-substituted alkyl or aryl alkyl thionitroethenamine. This compound may be reacted with a suitable amine to produce compounds containing the pharmaceutical ly active grouping -NHC( = CHNO2)NHX, wherein X represents an alkyl, arylalkyl or heterocyclic alkyl group.