PROCESS FOR MAKING A CYCLODEXTRIN

摘要

Sulfoalkyl ether cyclodextrins are produced by a process of treating an unsubstituted cyclodextrin starting material with an alkyl sultone in the presen ce of a base. The base is added in a stepwise, pH controlled manner so that substantiall y the entire initial charge of cyclodextrin starting material is at least partiall y reacted. Additional base is then added to complete the reaction, and residual alkyl sulto ne is destroyed. The product advantageously contains low levels of both residual cyclodextrin and residual alkyl sultone.