PROCESS FOR THE PREPARATION OF TRANSDERMAL THERAPEUTIC SYSTEM HAVING PHYSOSTIGMINE AS THE ACTIVE INGRADIENT

摘要

The invention refers to the procedure for the preparation of transdermal therapeutic system for the application of physostigmine to the skin consisting of the cover layer impermeable to the active ingredient, of the clinging and sticking reservoir layer and possibly removable protective layer. It is characterised by the fact that there is a textile surface formation on the prefabricated, self-adhesive matrix layer which is possibly equipped with the removable protective layer and that physostigmine or one of its pharmaceutically acceptable salts in the solution at the formation of the depot of the active substance is placed on the textile surface formation and then the matrix and the depot of the active substance are equipped with the cover layer.