Fibronectin antagonists as therapeutic agents and broad-spectrum enhancers of antibiotic therapy

摘要

The invention is directed to therapeutic use of compounds that function as inhibitors of microbial intracellular invasion of or adherence to host mammalian cells. Co-administration of the inhibitory compound with an antibiotic, such as penicillin, that inefficiently permeates mammalian cell membranes increases the efficacy of the antibiotic therapy.