| 发明名称 |
Composition and method to prevent graft rejection and other counter-adaptive t lymphocyte mediated immune responses |
| 摘要 |
A method is provided for preventing and reversing acute allograft rejection wherein both the CD80/CD86:CD28/CTLA-4 interaction and the CD40:CD154 interaction are interrupted. The effect of the method on treating autoimmune diseases and allergy is also set forth. |
| 申请公布号 |
AU7956798(A) |
申请公布日期 |
1998.12.30 |
| 申请号 |
AU19980079567 |
申请日期 |
1998.06.10 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF;WISCONSIN ALUMINI RESEARCH FOUNDATION |
发明人 |
DAVID M HARLAN;ALAN D. KIRK;STUART J. KNECHTLE |
| 分类号 |
A61K45/00;A61K38/00;A61K38/17;A61K39/395;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K14/705;C07K16/28;C12P21/08 |
主分类号 |
A61K45/00 |
| 代理机构 |
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代理人 |
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