TRANSGENIC RABBITS EXPRESSING CD4 AND CHEMOKINE RECEPTOR

摘要

The invention provides transgenic rabbits and transgenic rabbit cells expessing CD4 and a human chemokine receptor such as CXR4 or CCR5. The invention also provides methods of generating the transgenic rabbit. The double transgene is either generated by introducing the two transgenic entities into a fertilized pronucleus or by breeding two transgenic rabbits each ahving one of the transgenic entities. The rabbit may be infected with HIV.