HUMAN JAGGED POLYPEPTIDE, ENCODING NUCLEIC ACIDS AND METHODS OF USE
摘要
The present invention provides a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.
申请公布号
WO9858958(A2)
申请公布日期
1998.12.30
申请号
WO1998US13207
申请日期
1998.06.25
申请人
UNIVERSITY OF WASHINGTON;THE CHILDREN'S HOSPITAL OF PHILADELPHIA;LI, LINHENG;HOOD, LEROY;KRANTZ, IAN, D.;SPINNER, NANCY, B.
发明人
LI, LINHENG;HOOD, LEROY;KRANTZ, IAN, D.;SPINNER, NANCY, B.