| 摘要 |
<p>A process for the preparation of a compound of formula (I), wherein Y is a group that is inert for the reactions, preferably a hydrocarbyl; and m is from 0 to 4, preferably 0; in which process a) a compound of formula (II), wherein X is chlorine, bromine or iodine, preferably bromine, and Y and m are as defined for formula (I), is reacted with a vinylether of formula (IIIa) or an enamide of formula (IIIb): CH2=CH-OR1 (IIIa), CH2=CH-N(R2)-CO-R3 (IIIb), wherein R1 and R2 are each independently of the other C1-C8alkyl, C2-C8alkenyl, C1-C8alkoxyalkyl, C3-C6cycloalkyl, phenyl-C1-C2alkyl or C1-C8acyl, which groups are optionally substituted, R3 is C1-C8alkyl, C2-C8alkenyl, C1-C8alkoxyalkyl, C3-C6cycloalkyl or phenyl-C1-C2alkyl, which groups are optionally substituted, in a solvent, in the presence of a base and of a catalytic amount of a palladium compound comprising a monodental or bidental phosphine ligand; b) the resulting intermediate of formula (IVa) and resp. (IVb), is hydrolyzed to the compound of formula (I).</p> |
