HUMAN IMMUNODEFICIENCY VIRUSES CAUSING AIDS IN A NONHUMAN PRIMATE

摘要

An isolated human immunodeficiency virus (HIV) type 1, having the identifying characteristics of HIV isolate JC and assigned AIDS Reagent Program Catalog Number 3523, was isolated from an HIV-infected chimpanzee that developed AIDS. This chimpanzee represents the first known animal model of HIV-1 induced AIDS. The substantially full-length (infectious) nucleotide sequences of the HIV-1JC and of HIV-1NC molecular clones are provided herein. This HIV-1JC and HIV-1NC isolates are useful for the preparation of recombinant, attenuated and subunit vaccines, as well as for the preparation of challenge stocks. It is also used as a diagnostic reagent in screening for the presence of HIV-1 in biological samples.