| 摘要 |
The present invention provides a mammalian cell in which expression of a gene coding for a serine protease, especially hepsin, has been functionnally interrupted or suppressed. In a preferred embodiment, suppression of the serine protease gene, e.g., a hepsin gene, is achieved by, the insertion into it, a nucleotide sequence effective to disrupt its expression. The invention especially relates to a mammal containing one or more cells in which expression of the serine protease gene is functionally inactivated or interrupted. |
