发明名称 |
ANTI-CD40L IMMUNOTOXINS FOR THE TREATMENT OF DISEASES |
摘要 |
An immunotoxin molecule is described which comprises an antibody specific for human CD40L antigen located on the surface of a human cell, coupled to a toxin molecule or active fragment thereof, wherein the binding of the immunotoxin to the CD40L molecule results in the killing of the CD40L expressing cell. The toxin molecule is especially a type-1 ribosome inactivating protein, or an active fragment thereof. The immunotoxin can be used for the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus, or T-cell malignancies. |
申请公布号 |
CA2294223(A1) |
申请公布日期 |
1998.12.30 |
申请号 |
CA19982294223 |
申请日期 |
1998.06.22 |
申请人 |
PANGENETICS B.V. |
发明人 |
DEN HARTOG, MARCEL THEODORUS;DE BOER, MARK |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K47/48;A61P19/02;A61P25/00;A61P25/02;A61P29/00;A61P35/00;A61P35/02;A61P37/06;C07K1/22;C07K14/415;C07K16/28;C12P21/02;C12P21/08;(IPC1-7):A61K47/48 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|