Overexpression of cardiac receptors for myocardial protection

摘要

The invention relates to administration of the adenosine A1 receptor to a host animal to improve myocardial tolerance to ischemia. Methods of providing the adenosine receptor include transgenic expression and gene therapy, and also upregulation of endogenous adenosine receptors using drugs or other therapeutic substances. The adenosine receptor may be administered in combination with one or more additional agents which enhance to activity of the adenosine receptor, or the binding activity of the adenosine receptor to its ligand.