CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVES

摘要

Quinolone derivatives represented by general formula (I), salts thereof, and hydrates thereof of both, having potent antimicrobial activities against various bacteria including resistant strains and being highly safe: wherein R<1> represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R<2> represents a halogenomethoxyl or alkoxyl group; R<3> represents an alkyl, alkenyl, halogenoalkyl, cyclic alkyl, heteroaryl, alkoxyl, or alkylamino group; R<4> represents a hydrogen atom or a phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl, or phenylalkyl group. The above substituents may be further substituted.