| 摘要 |
Methods and compositions are provided for the modulation of cytokine production by T helper cells and antigen-presenting cells. Compositions are provided that regulate the production of cytokines during the course of an immune response. The cytokine regulatory factor is produced by antigen presenting cells, and can act on uncommitted CD4 <+> cells to cause them to commit to Th1 cytokine phenotype, on mature, committed Th1 type T cells to decrease the synthesis of pro-inflammatory cytokines, and on macrophages to decrease the production of pro-inflammatory cytokines. The subject compositions can be used in diagnosis or therapy. |
