Methylene blue for the treatment or prophylaxis of encephalopathy caused by ifosfamide

摘要

PCT No. PCT/GB94/02494 Sec. 371 Date Oct. 18, 1996 Sec. 102(e) Date Oct. 18, 1996 PCT Filed Nov. 14, 1994 PCT Pub. No. WO95/13079 PCT Pub. Date May 18, 1995The encephalopathy caused by ifosfamide and similarly acting compounds can be prevented or treated by the administration of methylene blue or another compound which is able to oxidize a reduced flavin moiety. Pyritinol is able to reduce other aspects of ifosfamide toxicity.