| 摘要 |
<p>The present invention provides a local drug delivery film, which is characterize d by comprising, as release control component, polymer mixture consisting of polycaprolactone having molecular weight of 30,000 - 60,000 and polycaprolactone having molecular weight less than 1,000 in a ratio of 1:1 - 4:1, and as active componen t, periodontal therapeutic agent. The present local drug delivery film is prepared by admixing homogeneously active component with m elted polymer mixture and pressing into film. And the present drug delivery film has excellent sustained release pattern and excellent treatment effect in oral disease with release amount 1.7 mg which is 0.12 % of prescription amount, 1400 mg, for adult s during 7 days and provides the application stability into human body.</p> |
