Therapeutic antiangiogenic compositions and methods

摘要

Isolated endostatin protein that is an inhibitor of endothelial cell proliferation and angiogenesis. Endostatin protein has a molecular weight of approximately 18 kDa as determined by non-reducing gel electrophoresis or approximately 20 kDa as determined by reducing gel electrophoresis. Endostatin protein corresponds to a C-terminal fragment of collagen type XVIII, and the protein can be isolated from the murine hemangioendothelioma EOMA cell line.