发明名称 |
Chemokine N-terminal deletion mutations |
摘要 |
The invention relates to mutant chemokines and pharmaceutical compositions thereof, wherein the mutant inhibits the corresponding endogenous chemokine from binding or activating a responsive receptor. The claimed mutant chemokines can be administered to a patient for the treatment or prophylaxis of a chemokine-mediated disease. The invention further relates to isolated DNAs encoding the mutant chemokines, vectors and recombinant host cells containing the same.
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申请公布号 |
US5854412(A) |
申请公布日期 |
1998.12.29 |
申请号 |
US19970956708 |
申请日期 |
1997.10.23 |
申请人 |
DANA-FARBER CANCER INSTITUTE |
发明人 |
ROLLINS, BARRETT;ZHANG, YUJUN |
分类号 |
C12N15/09;A61K38/00;A61P1/00;A61P9/08;A61P9/10;A61P11/00;A61P23/00;A61P29/00;A61P37/00;A61P43/00;C07K14/52;C12N15/19;C12P21/02;C12R1/91;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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