| 发明名称 |
A NEW PHYSICALLY STABLE SOLID FORM OF A FLUOROQUINOLONE |
| 摘要 |
Novel crystal forms of the fluoroquinolone, [S-(R*,S*)]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-[1-(methylamino)ethyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which, Form III exhibits greatest stability and decreased hygroscopicity. |
| 申请公布号 |
HUT77946(A) |
申请公布日期 |
1998.12.28 |
| 申请号 |
HU19980000950 |
申请日期 |
1995.11.08 |
| 申请人 |
PHARMACIA & UPJOHN CO. |
发明人 |
ALDRICH,DALE S.;BERGREN,MICHAEL S.;CHAO,ROBERT SHIH-LIANG;DUNN,MICHAEL J.;JEGANATHAN,AZHWARSAMY;SCHINZER,WILLIAM C.;YU,XUANQIANG |
| 分类号 |
A61K31/44;A61K31/4427;A61P31/04;C07D401/04 |
主分类号 |
A61K31/44 |
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