| 摘要 |
FIELD: organic chemistry, chemistry of nucleosides. SUBSTANCE: invention describes new 3'-(5-R-tetrazole-2-yl)-thymidines of the formula (I) <EMI ID=0.358 HE=60 WI=48 TI=CHI> where R - hydrogen or lower alkyl exhibiting antiviral activity with respect to human immunodeficiency virus (HIV) and avian myeloblastosis virus (AMV), and a method of synthesis of 3'-(5-R-tetrazole-2-yl)-thymidines. Method involves treatment of 5'-O-protected 2,3'-anhydrothymidine with tetrazole derivative of the general formula (II) <EMI ID=0.359 HE=24 WI=27 TI=CHI> where R - as indicated above in the presence of trialkylamine in medium of aprotonic dipolar solvent followed by hydrolytic splitting off a protective 5'-O-benzoyl group and isolation of the end product. Synthesized compounds are used in medicine for treatment of patients and animals with viral infections. EFFECT: new thymidine derivatives indicated above, improved method of synthesis. 2 cl, 3 tbl, 3 exi |
