AN ITRACONAZOLE EXHIBITING AN IMPROVED SOLUBILITY, A METHOD OF PREPARING THE SAME AND A PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING THE SAME

摘要

The particle diameter of itraconazole, insoluble drug, is reduced and crystallinity thereof is changed from crystalline into amorphous, increasing water solubility and a dissolution rate thereof . The improved itraconazole is applied to an oral adminstration drug.