| 发明名称 |
COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE |
| 摘要 |
Novel compounds of formula (1.0) are disclosed. In formula (1.0) a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
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| 申请公布号 |
CA2294351(A1) |
申请公布日期 |
1998.12.23 |
| 申请号 |
CA19982294351 |
申请日期 |
1998.06.15 |
| 申请人 |
SCHERING CORPORATION |
发明人 |
DOLL, RONALD J.;REMISZEWSKI, STACY W.;ALVAREZ, CARMEN;LALWANI, TARIK |
| 分类号 |
A61K31/45;A61K31/4545;A61P35/00;A61P43/00;C07D401/04;C07D401/14;C07D405/14;C07D413/14;C07D491/10;C07D491/113;C07D495/10;C07F7/18;(IPC1-7):C07D401/08;A61K31/55 |
主分类号 |
A61K31/45 |
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