PREPARATION OF GEMCITABINE HYDROCHLORIDE, 1-(2'-DEOXY-2',2'-DIFLUORO-D-RIBOFURANOSYL)-4-AMINOPYRIMIDIN- 2-ONE HYDROCHLORIDE

摘要

This invention provides a process for preparing gemcitabine hydrochloride which comprises deblocking beta -1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-amin opyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol in an environment essentially free of water; treating the resulting solution with hydrochloric acid and an antisolvent; and recovering the resulting solid gemcitabine hydrochloride.