| 发明名称 |
METHODS OF INCREASING THE BIOAVAILABILITY OF STABLE CRYSTAL POLYMORPHS OF A COMPOUND |
| 摘要 |
The present invention relates to methods of increasing the bioavailability of the most stable crystalline form of a compound. The invention also relates to particles of the most stable crystalline form of a compound having an average particle size of less than 400 nm. The invention further relates to pharmaceutical compositions comprising these particles and the use of such pharmaceutical compositions for treating diseases, such as HIV.
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| 申请公布号 |
WO9857648(A1) |
申请公布日期 |
1998.12.23 |
| 申请号 |
WO1998US12474 |
申请日期 |
1998.06.16 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHATURVEDI, PRAVIN, RAMSEWAK;BOGER, JOSHUA, S.;TUNG, ROGER, DENNIS |
| 分类号 |
A61K9/14;A61K31/216;A61K31/352;A61K31/427;A61K31/4709;A61K31/4725;A61K31/496;A61K31/513;A61K31/551;A61K31/635;(IPC1-7):A61K31/635;A61K9/51 |
主分类号 |
A61K9/14 |
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