| 摘要 |
Disclosed are novel compounds of Formula (I), wherein W is H or halo; X is H, halo, CH3, isopropyl, t-butyl, cyclopropyl, (a) or (b); Y and Z are independently selected from the group consisting of halo, CH3, OCH3, CF3, OCF3 and CH2OH; R is R'-(CH2)nC(O)-, R'-(CH2)nSO2- or R'-OC(O)-, wherein n is 0 to 2; and R' is aryl, heteroaryl or heterocycloalkyl. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of Formula (I) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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