| 摘要 |
<p>Compounds of formula (I) useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells farnesyl protein transferase inhibitors are disclosed or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein, R and R2 are halo; R?1 and R3¿ are H and halo, provided that at least one of R?1 and R3¿ is H; X is N, CH or C, when the double bond is present at the C-11 position; R4 is =O, -NHOH, -N=NHR6, -N=NHSO¿2R?6, -N=NHCOR6, -N=NHCONH¿2?, -N=NHCOCONH2, (H, OH), (H, -OR?6¿), (H, -OCOR6), (H, OSO¿2R?6) or -E-(CH¿2?)n1-G-, wherein n1 is 1 to 5, and E and G are O, S or N, and are joined to the same carbon to form a cyclic structure; R?5¿ is H, lower alkyl, or optionally substituted aryl, heteroaryl, aralkyl, heteroaralkyl or heterocycloalkyl-alkyl; R6 is lower alkyl or optionally substituted aryl, heteroaryl, aralkyl, heteroaralkyl or heterocycloalkyl-alkyl; R?7, R8 and R9¿ are independently selected from the group consisting of H, lower alkyl, aryl, and aralkyl; and n is 0-5.</p> |
