QUINOLINE DERIVATIVES AS PDE IV AND/OR TNF INHIBITORS

摘要

Compounds of formula (i) wherein R1 represents C1-6 alkoxy (alkyl portion optionally substituted with one or more halogens) or thioalkyl; Q represents an aryl or heteroaryl ring, attached through any appropriate atom and optionally substituted at any position(s) with one or more substituents R5. The compounds can be used to treat disease states, for example disease states associated with proteins that mediate cellular activity, for example by inhibiting tumour necrosis factor and/or by inhibiting phosphodiesterase IV.