发明名称 |
HAMMERHEAD RIBOZYMES WITH EXTENDED CLEAVAGE RULE |
摘要 |
Disclosed are compositions having an RNA-cleavage activity, as well as their use for cleaving RNA-substrates in vitro and in vivo. The compositions contain an active center, the subnits of which are selected from nucleotides and/or nucleotide analogues, as well as flanking regions contributing to the formation of a specific hybridization with an RNA substrate. Preferred compositions form, in combination with an RNA substrate, a structure resembling a hammerhead structure. The active center of the disclosed compositions is characterized by the presence of I<15.1> which allows cleavage of RNA substrates having C<16.1>.
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申请公布号 |
WO9858058(A1) |
申请公布日期 |
1998.12.23 |
申请号 |
WO1998US12663 |
申请日期 |
1998.06.17 |
申请人 |
INNOVIR LABORATORIES, INC. |
发明人 |
LUDWIG, JANOS;SPROAT, BRIAN, S. |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61P43/00;C12N9/22;C12N15/113;C12Q1/68;(IPC1-7):C12N15/11;C12N9/00;C07H21/00;A61K31/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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