发明名称 |
Preparation of ionically cross-linked polyphosphazene microspheres by coacervation |
摘要 |
A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a solution containing a salt of a monovalent ion such as a salt of a Group I element (for example, NaCl) to form a dispersion containing polyphosphazene coacervate microdroplets. The dispersion then is admixed with a solution containing a salt of a multivalent ion, such as a salt of a Group II element (for example, CaCl2) to form a suspension of polyphosphazene microspheres. The polyphosphazene microspheres then are recovered from the suspension. Such method enables one to obtain high yields of microspheres having a controlled size distribution. Polyphosphazene microspheres containing biological material can be produced by providing a biological material in the polyphosphazene solution that is mixed with the solution containing a salt of a monovalent ion. The biological material may be an antigen or other biological material selected from proteins, nucleic acids, polysaccharides and synthetic compounds having biological activity. |
申请公布号 |
ZA9705508(B) |
申请公布日期 |
1998.12.21 |
申请号 |
ZA19970005508 |
申请日期 |
1997.06.20 |
申请人 |
VIRUS RESEARCH INSTITUTE , INC. |
发明人 |
ALEXANDER K. ANDRIANOV;JIANPING CHEN |
分类号 |
C12N11/08;A61K9/00;A61K9/16;A61K9/50;A61K31/7088;A61K31/711;A61K31/715;A61K38/00;A61K39/00;A61K39/05;A61K39/08;A61K39/095;A61K39/102;A61K39/13;A61K39/145;A61K39/15;A61K39/165;A61K39/20;A61K39/21;A61K39/245;A61K39/29;A61K47/34;A61K48/00;A61P31/04;A61P31/14;A61P31/16;A61P31/18;A61P31/20;A61P31/22;B01J13/08;C07F9/06;C07K17/08;C08G79/02;C08L85/02 |
主分类号 |
C12N11/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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