| 发明名称 |
COMPOSITION AND METHOD TO PREVENT GRAFT REJECTION AND OTHER COUNTER-ADAPTIVE T LYMPHOCYTE MEDIATED IMMUNE RESPONSES |
| 摘要 |
A method is provided for preventing and reversing acute allograft rejection wherein both the CD80/CD86:CD28/CTLA-4 interaction and the CD40:CD154 interaction are interrupted. The effect of the method on treating autoimmune diseases and allergy is also set forth.
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| 申请公布号 |
CA2291338(A1) |
申请公布日期 |
1998.12.17 |
| 申请号 |
CA19982291338 |
申请日期 |
1998.06.10 |
| 申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE U.S. D EPARTMENT OF THE NAVY |
发明人 |
KNECHTLE, STUART J.;KIRK, ALLAN D.;HARLAN, DAVID M. |
| 分类号 |
A61K45/00;A61K38/00;A61K38/17;A61K39/395;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K14/705;C07K16/28;C12P21/08;(IPC1-7):A61K39/395 |
主分类号 |
A61K45/00 |
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