| 发明名称 |
CD28/CTLA-4 INHIBITING PEPTIDOMIMETICS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHOD OF USING SAME |
| 摘要 |
The present invention relates to peptidomimetics capable of inhibiting CD28 and/or CTLA-4 interaction with CD80 (B7-1) and CD86 (B7-2) and having a core amino acid sequence, LeuMetTyrProProProTyrTyr, corresponding to residues 2 to 9 of SEQ ID NO:1. The present invention also relates to pharmaceutical compositions and a method of treating pathologies and disorders which are improved by inhibition of CD28 and/or CTLA-4 interaction with CD80 and CD86.
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| 申请公布号 |
CA2293666(A1) |
申请公布日期 |
1998.12.17 |
| 申请号 |
CA19982293666 |
申请日期 |
1998.06.11 |
| 申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
BLECHNER, STEVEN;JAMESON, BRAD;EL TAYAR, NABIL;TEPPER, MARK |
| 分类号 |
A61K38/00;A61P37/06;A61P43/00;C07K7/04;C07K7/64;C07K14/705;(IPC1-7):A61K38/04;A61K38/12 |
主分类号 |
A61K38/00 |
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