发明名称 |
Verfahren zur Herstellung von Dinukleosid-Polyphosphat, Nukleosid-Polyphosphat oder Derivate davon |
摘要 |
A method for producing a dinucleoside polyphosphate, a nucleoside polyphosphate or a derivative thereof which comprises using adenosine-5'-triphosphate, polyphosphate or a derivative thereof and a sulfate as reaction substrates and forming a dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof via a two-stage reaction through the use of two enzymes, namely, adenosine-5'-triphosphate sulfurylase and diadenosine tetraphosphate phosphorylase as catalysts. Further, another method for producing a dinucleoside polyphosphate, a nucleoside polyphosphate or a derivative thereof which comprises using adenosine-5'-triphosphate, polyphosphate or a derivative thereof and a sulfate as reaction substrate in the presence of an enzyme capable of converting adenosine-5'-diphosphate into adenosine-5'-triphosphate, and forming the dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof via a two-stage reaction through the use of two enzymes, namely, adenosine-5'-triphosphate sulfurylase and diadenosine tetraphosphate phosphorylase as catalysts is provided. According to the present invention, highly pure dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof can be produced at a high yield and these products can be easily isolated and purified. |
申请公布号 |
DE69319369(T2) |
申请公布日期 |
1998.12.17 |
申请号 |
DE1993619369T |
申请日期 |
1993.04.16 |
申请人 |
UNITIKA LTD., AMAGASAKI, HYOGO, JP |
发明人 |
YAMAMOTO, HIDEKI, C/O UNITIKA LTD., UJI-SHI, KYOTO, JP;MANABE, MIKA, C/O UNITIKA LTD., UJI-SHI, KYOTO, JP;NAKAJIMA, HIROSHI, C/O UNITIKA LTD., UJI-SHI, KYOTO, JP |
分类号 |
C12P19/38;C12N9/10;C12N9/12;C12P19/32;C12R1/07;C12R1/865 |
主分类号 |
C12P19/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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