摘要 |
<p>A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated noncollagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein, and a therapeutically effective amount to stimulate bone growth of a bone growth factor in synergistic combination with said bone material. Spacers composed of the bone graft substitute composition and methods for using the spacers are also provided.</p> |