The present invention provides a monomeric insulin analog formulation stabilized against aggregation in which the buffering agent is either TRIS or arginine. The stable formulations of the present invention are useful for treating diabetes, and are particularly advantageous in treatment regimes requiring lengthy chemical and physical stability, such as, in continuous infusion systems.
申请公布号
WO9856406(A1)
申请公布日期
1998.12.17
申请号
WO1998US12218
申请日期
1998.06.11
申请人
ELI LILLY AND COMPANY;DEFELIPPIS, MICHAEL, ROSARIO;DOBBINS, MICHAEL, ALLEN;FRANK, BRUCE, HILL;LI, SHUN;REBHUN, DAWN, MARIE
发明人
DEFELIPPIS, MICHAEL, ROSARIO;DOBBINS, MICHAEL, ALLEN;FRANK, BRUCE, HILL;LI, SHUN;REBHUN, DAWN, MARIE