发明名称 |
PROCESS FOR PREPARING (1S,4R)- OR (1R,4S)-4-(2-AMINO-6-CHLORO-9-H-PURIN-9-YL)-2-CYKLOPENTENE-1-METHANOL |
摘要 |
Racemic or optically active 1-amino-4-(hydroxymethyl)-2- cyclopentene derivatives are obtained by acylation of 1-amino-2-cyclopentene-4- carboxylic acid with an acid halide, followed by reduction of the carboxyl group. - A method for the production of racemic or optically active 4-(hydroxymethyl)-2-cyclopentene derivatives of formula (XIII) involves acylation of a cyclopentene-4-carboxylic acid derivative of formula (XIV) (as the racemate or an optically active isomer) with a carboxylic acid halide of formula R1-CO-X (XI), followed by reduction of the resulting acid derivative (XV): - R1 = 1-4C alkyl, 1-4C alkoxy, aryl or aryloxy; - X = halogen |
申请公布号 |
CZ9801458(A3) |
申请公布日期 |
1998.12.16 |
申请号 |
CZ19980001458 |
申请日期 |
1998.05.11 |
申请人 |
LONZA AG |
发明人 |
BERNEGGER CHRISTINE DR.;URBAN EVA MARIA;BIRCH OLWEN MARY DR.;BURGDORF KURT;BRUX FRANK;ETTER KAY-SARA;BOSSARD PIERRE DR.;BRIEDEN WALTER DR.;DUC LAURENT DR.;GORDON JOHN;O MURCHU COLM DR.;GUGGISBERG YVES DR. |
分类号 |
C12P41/00;C07C231/18;C07C231/20;C07C233/23;C07C271/24;C07D209/94;C07D233/04;C07D233/74;C07D235/02;C07D237/06;C07D239/70;C07D473/40;C12P13/00;C12P13/02;C12P17/18;C12R1/01;C12R1/05;C12R1/06;C12R1/09;C12R1/19;C12R1/38;(IPC1-7):C07D239/70 |
主分类号 |
C12P41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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