发明名称 |
Reagents and methods for the diagnosis and treatment of diabetes and stiff man syndrome |
摘要 |
The invention provides fragments of GAD65 that are specifically reactive with at least one class of GAD65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.
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申请公布号 |
US5849506(A) |
申请公布日期 |
1998.12.15 |
申请号 |
US19950450755 |
申请日期 |
1995.05.25 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BAEKKESKOV, STEINUNN;RICHTER, WILTRUD;SHI, YUGUANG;NAMCHUK, MARK;KIM, JOHN |
分类号 |
A61K38/00;A61K39/395;A61P3/08;A61P3/10;A61P37/00;A61P43/00;C07K7/06;C07K7/08;C07K14/47;C07K16/40;C07K19/00;C12N9/88;C12N15/09;C12P21/00;C12R1/91;G01N33/564;G01N33/573;G01N33/68;G01N33/74;(IPC1-7):G01N33/531;G01N33/543 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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