| 摘要 |
PCT No. PCT/US94/01965 Sec. 371 Date Jan. 31, 1996 Sec. 102(e) Date Jan. 31, 1996 PCT Filed Mar. 4, 1994 PCT Pub. No. WO94/20515 PCT Pub. Date Sep. 15, 1994Disclosed are derivatives of gangliosides and of N-acyl-N-lyso-gangliosides, of N'-acyl-N'-lyso-gangliosides and N,N'-di- or poly-acyl-N,N'-di-lyso-gangliosides, in which at least one of the hydroxyl groups in the saccharide, sialic or ceramide residues is esterified with sulfuric acid, functional derivatives thereof, and their salts with either inorganic or organic bases and the acid addition salts, except persulfated derivatives at the hydroxyl, sialic and ceramide groups of the GM1, GD1a, GD1b and GT1b gangliosides. Such compounds have antineurotoxic and neurotogenic activity and may therefore be used in pharmaceutical preparations. Also a marked modulating effect on the expression of the CD4 molecule in immune system cells has been shown.
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