发明名称 |
BCR/ABL transgenic animals as models for Philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia |
摘要 |
The present invention relates to non-human transgenic animals which contain a transgene comprising a BCR/ABL gene fusion and which develop leukemia. In a preferred embodiment of the present invention, the transgenic animals exhibit a rapid induction of acute leukemia. The present invention offers the advantage of providing, for the first time, a non-human transgenic animal model system which carries the BCR/ABL gene fusion characteristic of the Philadelphia chromosome and which develops leukemia in a manner directly analogous to the clinical progression of chronic myelogenous leukemia (CML) and/or acute lymphoblastic leukemia (ALL) in humans. This model system for human leukemia may be valuable in obtaining a better understanding of CML and ALL and in developing effective therapeutic regimens.
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申请公布号 |
US5849996(A) |
申请公布日期 |
1998.12.15 |
申请号 |
US19950463467 |
申请日期 |
1995.06.05 |
申请人 |
CHILDRENS HOSPITAL OF LOS ANGELES |
发明人 |
GROFFEN, JOHN;HEISTERKAMP, NORA;PATTENGALE, PAUL K. |
分类号 |
A01K67/027;C07K14/82;C12N15/85;G01N33/574;(IPC1-7):C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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