Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors

摘要

PCT No. PCT/EP96/01165 Sec. 371 Date Dec. 4, 1996 Sec. 102(e) Date Dec. 4, 1996 PCT Filed Mar. 14, 1996 PCT Pub. No. WO96/32380 PCT Pub. Date Oct. 17, 1996The present invention relates to indol-3-ylmethylene-2-oxindole derivatives which are useful as tyrosine kinase inhibitors. The compounds are suitable for use as anti-proliferative agents, anti-metastatic agents, anti-cancer agents, and in the control of angiogenesis and in inhibiting the development of atheromatous and an immunomogulating agents.