Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

摘要

Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R2 are independently selected from halo; R1 and R3 are independently selected from the group consisting of H and halo, provided that at least one of R1 and R3 is H; R4 is or R5; R5 is and the remaining variables are as defined in the specification.