Aminotetralone derivatives and preparation process thereof

摘要

PCT No. PCT/JP96/00390 Sec. 371 Date Aug. 21, 1997 Sec. 102(e) Date Aug. 21, 1997 PCT Filed Feb. 21, 1996 PCT Pub. No. WO96/26181 PCT Pub. Date Aug. 29, 1996The present invention pertains to a process for the preparation of Compound (4) through the below-described reaction route: <IMAGE> <IMAGE> <IMAGE> +TR <IMAGE> wherein R1 and R2 each represents H, halogen, OH or C1-6 alkyl group; X and Y each represents a protected amino group and n stands for 0 to 4. According to the above process, an aminotetralone derivative which is an intermediate useful for an industrial preparation of a camptothecin derivative can be obtained in a convenient manner and in a high yield.