AGENT FOR INHIBITING SYNTHESIS OF PYRANOPYRANONE COMPOUND-CONTAINING HSP47

摘要

PROBLEM TO BE SOLVED: To obtain the subject medicine capable of inhibiting collagen synthesis and treating morbid state of accentuation of cell matrix production by including a pyranopyranone compound as an active ingredient. SOLUTION: This medicine has a compound of formula I [R' is a hexose residue obtained by eliminating OH at 1 position of hexose; R is a group of formula II (R is H, an alkyl, etc.; R and R are each H, an amino-protecting group or R and R together form trimethylene, etc.) or H]. The compound of, formula I includes swertiamarin which is obtained by extracting swertia Herb which is a crude medicine. The medicine has action improving accentuation of collagen synthesis observed in cells attacked by diseases exhibiting morbid state of accentuation of extracellular matrix production, e.g. liver cirrhosis, interstitial lung disease, chfonic renal failure, cardiac hypertrophy, postoperative cicatrix, burn cicatrix, keloid or hypertrophic cicatrix caused after traffic accident, scleroderma, arteriosclerosis or rheumatoid arthritis and effectively can treat the above diseases.