| 摘要 |
This invention refers to a new process for the synthesis of (S)-N,N'-bis[(2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzendicarboxamide, of formula (III), do-1,3-benzendicarboxylic acid dichloride characterized by a new step of chromatographic purification through resins of (S)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzendicarboxylic acid dichloride, which enables the direct conversion to the compound of formula (III), without preventive isolation.
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